Hell yeah! Oooooosaka! If ever a city could be described as having 'flavor,' it'd be Osaka.
You can start by stuffing your face with takoyaki and okonomiyaki (and don't stop). Visit historical Osaka Castle and Sumiyoshi Shrine. Cheer for the Hanshin Tigers. Watch sumo and bunraku. Relax your buns at spa world, the only spa with an indoor roller coaster (that we know of). And don't forget the Glico man.
No matter what you do, it'll be a unique experience, thanks to Osaka's vibrant culture and unique outlook on life.